Description

2-Difluoromethoxy-Benzenesulfonyl Chloride is a high-purity, reactive organosulfur intermediate essential for advanced chemical synthesis. Its core value lies in the versatile sulfonyl chloride functional group, which enables efficient introduction of the sulfonyl moiety into target molecules under controlled conditions. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the production of modern herbicides and fungicides that incorporate difluoromethoxy and sulfonyl groups for enhanced activity.
• Material Science Research: Serves as a precursor for creating specialized polymers and functional materials with specific surface properties.
• Chemical Biology Probes: Employed in the development of activity-based probes and labeling reagents for studying biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	2-Difluoromethoxy-Benzenesulfonyl Chloride
CAS No.	77798-10-8
Molecular Formula	C7H5ClF2O3S
Molecular Weight	242.63 g/mol
Synonyms	o-(Difluoromethoxy)benzenesulfonyl chloride; Benzenesulfonyl chloride, 2-(difluoromethoxy)-; 2-(Difluoromethoxy)benzenesulfonyl chloride; 1-(Difluoromethoxy)-2-sulfonylchloridobenzol; 2-DFMO-BSC
EINECS	Contact for details

Quality Control

Our 2-Difluoromethoxy-Benzenesulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with ICH guidelines for impurities and can provide material suitable for use in regulated environments under appropriate quality agreements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.