Description

Benzenesulfonyl Chloride, 2-Chloro-5-(Trifluoromethoxy)- is a specialized aromatic sulfonyl chloride derivative, serving as a high-value synthetic intermediate in advanced organic chemistry. Its core value lies in its dual reactive sites—the sulfonyl chloride group and the electron-deficient aromatic ring—which enable precise functionalization for creating complex molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to construct active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs), including potential candidates for therapeutic agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethoxy group for enhanced biological activity and stability.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and functional materials.
• Chemical Research & Development: A versatile reagent for introducing the benzenesulfonyl moiety in medicinal chemistry and process optimization studies.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of specialized dyes and pigments where sulfone groups contribute to color fastness and solubility properties.

Basic Information

Product Name	Benzenesulfonyl Chloride, 2-Chloro-5-(Trifluoromethoxy)-
CAS No.	77797-65-0
Molecular Formula	C7H3Cl2F3O3S
Molecular Weight	295.06 g/mol
Synonyms	2-Chloro-5-(trifluoromethoxy)benzenesulfonyl chloride; 1-Chloro-4-(trifluoromethoxy)-2-sulfonylchloridobenzene; 2-Chloro-α,α,α-trifluoro-p-anisolesulfonyl chloride; 2-Chloro-5-(trifluoromethoxy)benzene-1-sulfonyl chloride; 5-Chloro-2-(trifluoromethoxy)benzenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our Benzenesulfonyl Chloride, 2-Chloro-5-(Trifluoromethoxy)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.