Description

Palytoxin CAS NO 77734-92-0 is a highly potent, non-proteinaceous marine toxin of significant scientific and pharmacological interest. Its complex polyol structure makes it one of the most powerful non-peptidic toxins known, primarily studied for its unique mechanism of action on the Na+/K+-ATPase pump. This product is essential for advanced research in toxicology, pharmacology, and marine biochemistry, serving as a critical reference standard and investigative tool. It is primarily utilized by research institutions, pharmaceutical R&D departments, and specialized testing laboratories.

Application

• Pharmacological Research: Used as a potent probe to study ion channel function, specifically the transformation of the Na+/K+-ATPase into a non-selective cation channel.
• Toxicology & Risk Assessment: Serves as a critical reference standard for the detection and quantification of palytoxin and its analogs in environmental, clinical, and food safety testing (e.g., shellfish monitoring).
• Biomedical Research: Investigated for its effects on cell signaling, apoptosis, and cytoskeleton structure due to its profound impact on cellular ion homeostasis.
• Antitumor & Bioactivity Studies: Explored in preclinical research for potential bioactivities, given its ability to induce potent cytotoxic effects in various cell lines.
• Marine Toxin Standard: Essential for calibrating analytical equipment (LC-MS/MS, HPLC) and validating methods in monitoring programs for marine biotoxins.
• Neuroscience Research: Utilized to investigate neuronal excitotoxicity and mechanisms of cell death related to ion dysregulation.

Basic Information

Product Name	Palytoxin
CAS No.	77734-92-0
Molecular Formula	C129H223N3O54
Molecular Weight	2680.3 g/mol
Synonyms	Palytoxin; PTX; (3S,6R,7S,10S,13R,14R,16R,19R,20R,23S,24R,29S,33S,34R,36R,39S,40R,43S,46S,47R,50S,53S,56R,57S,60S,63R,64R,67S,68S,71S,72R,75S,76R,79S,82S,85S,86R,89S,92S,95S,96R,99S,102S,105S,106R,109S,112S,115S,116R,119S,122S,125S,128S,131S,134S,137S,140S,143S,146S,149S,152S,155S,158S,161S,164S,167S,170S,173S,176S,179S,182S,185S,188S,191S,194S,197S,200S,203S,206S,209S,212S,215S,218S,221S,224S,227S,230S,233S,236S,239S,242S,245S,248S,251S,254S,257S,260S,263S,266S,269S)-Form; Marine Toxin from Palythoa spp.
EINECS	Contact for details

Quality Control

Our Palytoxin is produced and handled under strict quality protocols to ensure the highest standards of purity and identity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity (HPLC), identity confirmation (NMR, MS), and solvent content. We adhere to rigorous analytical procedures to guarantee batch-to-batch consistency and reliability for your critical research needs. COAs are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) and strictly light-sensitive nature, this material must be stored under an inert atmosphere (e.g., argon or nitrogen) in a freezer at -20°C or below. The container should be allowed to reach room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum corresponds to reference
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.