Description

11A-Hydroxyprogesterone 11-Glucuronide is a high-purity conjugated metabolite of progesterone, formed via glucuronidation. This compound is of significant value as a critical reference standard and analytical reagent for metabolic and pharmacokinetic studies. It is primarily needed by pharmaceutical R&D laboratories, clinical research organizations, and diagnostic manufacturers for precise quantification and method validation in steroid hormone analysis.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the quantitative analysis of progesterone metabolites in drug development and bioequivalence studies.
• Clinical Research & Diagnostics: Essential for developing and calibrating LC-MS/MS and immunoassay kits to measure hormone levels in biological matrices like serum and urine.
• Metabolic Pathway Investigation: Serves as a key tool for studying Phase II metabolism, specifically glucuronidation pathways, of steroid hormones.
• Toxicology & Doping Control: Employed in forensic and sports anti-doping laboratories for the accurate identification and confirmation of endogenous steroid profiles.
• Biochemical Research: Utilized in enzymatic studies related to UGT (UDP-glucuronosyltransferase) activity and steroid hormone conjugation mechanisms.

Basic Information

Product Name	11A-Hydroxyprogesterone 11-Glucuronide
CAS No.	77710-64-6
Molecular Formula	C27H38O9
Molecular Weight	506.59 g/mol
Synonyms	11α-Hydroxyprogesterone 11-glucuronide; 11α-Hydroxyprogesterone 11-β-D-Glucopyranosiduronic Acid; 11α-Hydroxypregn-4-ene-3,20-dione 11-glucuronide; 11α-Hydroxyprogesterone Glucuronide; 11α-OH-PG Glucuronide; 11α-Hydroxyprogesterone 11-Gluc; Pregn-4-ene-3,20-dione, 11α-hydroxy-, 11-(β-D-glucopyranosiduronic acid)
EINECS	Contact for details

Quality Control

Our 11A-Hydroxyprogesterone 11-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by spectroscopic methods, to ensure it meets the stringent requirements for use as a reference material. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.