Description

5'-Hydroxypiroxicam is a key pharmaceutical intermediate and metabolite of the non-steroidal anti-inflammatory drug (NSAID) piroxicam. This compound matters for its critical role in drug metabolism studies and as a reference standard for analytical and bioanalytical method development. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) and finished dosage forms.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of piroxicam and its metabolites in drug substances and products.
• Metabolite Studies: Essential for in vitro and in vivo pharmacokinetic and pharmacodynamic research to understand the metabolic pathway and biological activity of piroxicam.
• Analytical Method Development: Serves as a critical component in developing and validating HPLC, LC-MS, and GC-MS methods for impurity profiling and assay determination.
• Impurity Standard: Employed as a specified impurity in the quality control of piroxicam API to ensure compliance with pharmacopoeial standards (e.g., USP, EP).
• Biomedical Research: Utilized in biochemical research to investigate the mechanism of action, toxicity, and degradation products of oxicam-class NSAIDs.
• Custom Synthesis: Acts as a building block for the synthesis of novel piroxicam analogs and derivatives in medicinal chemistry programs.

Basic Information

Product Name	5'-Hydroxypiroxicam
CAS No.	77459-78-0
Molecular Formula	C15H13N3O5S
Molecular Weight	347.35 g/mol
Synonyms	5'-Hydroxy Piroxicam; 4-Hydroxy-2-methyl-N-(5-methyl-3-oxo-1,2-dihydro-1,2-benzisoxazol-6-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide; Piroxicam 5'-Hydroxy Metabolite; 5'-OH-Piroxicam; 5'-Hydroxy-1,2-dihydro-1,2-benzisoxazole Piroxicam Derivative; 6-(3-Carboxy-1,1-dioxo-2-methyl-4-oxo-1,2-dihydro-2H-1,2-benzothiazin-6-yl)-5-methyl-1,2-benzisoxazol-3(2H)-one
EINECS	Contact for details

Quality Control

Our 5'-Hydroxypiroxicam is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets high-purity standards suitable for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.