Description

Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-22-Demethyl-O3-(3-Methyl-1-Oxobutyl)- is a highly potent cytotoxic agent and a key structural derivative in the maytansinoid class of compounds. Its primary value lies in its role as a critical payload for the development of Antibody-Drug Conjugates (ADCs), enabling targeted cancer therapy with reduced systemic toxicity. This compound is essential for pharmaceutical R&D teams, medicinal chemists, and biopharmaceutical manufacturers focused on next-generation oncology therapeutics and targeted drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the potent cytotoxic warhead chemically linked to monoclonal antibodies for targeted cancer therapy.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for novel anti-cancer agents.
• Medicinal Chemistry: Acts as a core scaffold for the synthesis and structure-activity relationship (SAR) studies of new maytansinoid derivatives.
• Biopharmaceutical Manufacturing: Employed in the cGMP-compliant production of ADC-based therapeutics for various solid tumors and hematological malignancies.
• Cell Biology Studies: Utilized as a microtubule-disrupting agent to study mechanisms of cell division, apoptosis, and intracellular trafficking.

Basic Information

Product Name	Maytansine, O3-De2-(Acetylmethylamino)-1-Oxopropyl-22-Demethyl-O3-(3-Methyl-1-Oxobutyl)-
CAS No.	77353-70-9
Molecular Formula	C36H50ClN3O9
Molecular Weight	704.25 g/mol
Synonyms	DM1; Mertansine; N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine; Ansamitocin P-3′ derivative; Maytansinoid DM1; NSC-330507; (2S)-2-[[(3S,4S,5S,6R,8S,10S,11S,12R,13S,14S)-12-[[(2R)-4-[(2S)-2-[(acetyl-methylamino)methyl]-1-oxobutyl]-2-morpholinyl]carbonyl]-6-[(2S)-3-chloro-2-hydroxy-1-oxopropyl]-13-ethyl-4,8,10,12,14-pentamethyl-3,5,9,11-tetraoxo-1-oxa-4-azacyclotetradec-14-yl]thio]-1-oxopropyl] 3-mercaptopropanoate
EINECS	Contact for details

Quality Control

Our Maytansine derivative is manufactured under strict quality systems suitable for pharmaceutical development. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for every lot. Production can be aligned with cGMP guidelines for advanced clinical and commercial supply requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The material is strictly light-sensitive and should be handled under controlled conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 98.0%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.