Description

Maytansine, 2-De(Acetylmethylamino)-22-Demethyl- is a potent cytotoxic agent and a key synthetic derivative of the natural product maytansine. This compound is of critical importance in the development of targeted cancer therapies, specifically as a payload in Antibody-Drug Conjugates (ADCs). It is primarily needed by pharmaceutical R&D departments, biotech companies, and contract research organizations (CROs) focused on oncology drug discovery and advanced bioconjugation platforms.

Application

• Primary Payload for Antibody-Drug Conjugates (ADCs): Serves as the potent cytotoxic warhead linked to monoclonal antibodies for targeted cancer cell destruction.
• Oncology Research & Drug Discovery: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies for novel anticancer agents.
• Bioconjugation Chemistry Studies: Employed in developing and optimizing linker technologies for stable and effective ADC constructs.
• Mechanism of Action Studies: Utilized to investigate tubulin inhibition and mitotic arrest in various cancer cell lines.
• Process Development & Scale-up: Serves as a critical intermediate in the synthetic pathway for manufacturing advanced ADC therapeutics.

Basic Information

Product Name	Maytansine, 2-De(Acetylmethylamino)-22-Demethyl-
CAS No.	77353-68-5
Molecular Formula	C34H46ClN3O9
Molecular Weight	676.20 g/mol
Synonyms	DM1; Mertansine; Ansamitocin P-3 derivative; 2-Deacetyl-2-mercapto-1-methylethanol maytansinoid; N2-Deacetyl-N2-(3-mercapto-1-oxopropyl)-maytansine; Maytansinoid DM1; (3S,4R,5S,6R)-6-[(2R)-2-[(1S,2R)-1-Hydroxy-2-methyl-4-oxo-3-prop-2-en-1-yl-5-cyclopent-2-en-1-yl]ethyl]-4-methoxy-5-methyl-3-prop-1-en-2-yl-1-oxa-8-azaspiro[4.5]decane-2,7,10-trione
EINECS	Contact for details

Quality Control

Our Maytansine, 2-De(Acetylmethylamino)-22-Demethyl- (DM1) is manufactured under strict quality systems suitable for research and development use. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While not intended as a drug substance for human use without further processing, our quality protocols ensure high batch-to-batch consistency and reliability for critical R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Store in a dedicated, secure freezer away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.