Description

Maytansine, O3-Acetyl-O3-De2-(Acetylmethylamino)-1-Oxopropyl-22-Demethyl- is a highly potent, semi-synthetic derivative of the natural cytotoxin maytansine, designed for targeted therapeutic applications. This compound is a critical intermediate and payload in the development of Antibody-Drug Conjugates (ADCs), enabling the precise delivery of cytotoxic agents to cancer cells. It is essential for pharmaceutical R&D, process development, and the manufacturing of next-generation oncology therapeutics, offering researchers a key building block for innovative cancer treatments.

Application

• Primary Payload for Antibody-Drug Conjugates (ADCs): Serves as the cytotoxic warhead conjugated to monoclonal antibodies for targeted cancer therapy.
• Oncology Research & Development: Used in preclinical and clinical studies to evaluate the efficacy and mechanism of novel ADC constructs.
• Process Chemistry & Scale-Up: Acts as a key intermediate in the synthetic pathway for producing ADC payloads under cGMP conditions.
• Bioconjugation Studies: Employed in developing and optimizing linker technologies for stable and effective drug-antibody attachment.
• Reference Standard: Used as an analytical standard for quality control and regulatory filings of ADC-based pharmaceuticals.
• Drug Discovery: Investigated for its potential in other targeted delivery systems beyond traditional ADCs.

Basic Information

Product Name	Maytansine, O3-Acetyl-O3-De2-(Acetylmethylamino)-1-Oxopropyl-22-Demethyl-
CAS No.	77353-67-4
Molecular Formula	C37H51ClN4O10
Molecular Weight	747.28 g/mol
Synonyms	DM1; Mertansine; N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine; Ansamitocin P-3 derivative; Maytansinoid DM1; NSC-332598; (2S)-2-[[(3S,4S,5S,6R,8S,10S,11S,12R,13S,14S,16R,18S)-18-[[(2R)-1-[[(2R)-1-[[(2R)-1-hydroxy-3-[(2-sulfanylethyl)amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamoyl]-12-chloro-4,6,10,14-tetramethyl-3,5,8,11,13,16-hexahydro-2H-2,13-epoxy-6,10-methanocyclonona[3,4]benzo[1,2-f]azacyclododecene-11-carbonyl]oxy]-3-methylbutanoic acid
EINECS	Contact for details

Quality Control

Our Maytansine, O3-Acetyl-O3-De2-(Acetylmethylamino)-1-Oxopropyl-22-Demethyl- is manufactured and controlled to meet the stringent requirements for pharmaceutical intermediates. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable, ensuring consistency and traceability for critical R&D and development purposes. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. Due to its hygroscopic (moisture-sensitive) nature, the container must be sealed under dry conditions and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single unknown impurity ≤ 2.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.