Description

Didemnins are a class of cyclic depsipeptides originally isolated from marine tunicates, with Didemnin B being the most prominent member. These compounds are of significant interest due to their potent and diverse biological activities, including antiviral, antitumor, and immunosuppressive properties. They serve as critical research tools and lead compounds in pharmaceutical development, particularly for oncology and virology research programs targeting novel therapeutic mechanisms.

Application

• Pharmaceutical Research & Development: As a lead compound for investigating novel anticancer and antiviral agents, particularly in preclinical studies.
• Oncology Research: Study of apoptosis induction and cell cycle inhibition mechanisms in various cancer cell lines.
• Virology Studies: Exploration of antiviral activity against a range of DNA and RNA viruses in laboratory settings.
• Biochemical Tool: Used in molecular biology to study protein synthesis inhibition and its effects on cellular processes.
• Immunology Research: Investigation of immunosuppressive properties and their potential applications in autoimmune disease models.
• Marine Natural Product Chemistry: Serves as a reference standard and model compound for the synthesis and study of complex marine-derived peptides.

Basic Information

Product Name	Didemnins
CAS No.	77327-04-9
Molecular Formula	C57H89N7O15 (for Didemnin B)
Molecular Weight	1112.36 g/mol (for Didemnin B)
Synonyms	Didemnin B; NSC-325319; 4-L-Threonine-9-L-glutamine-15-glycine-2,6,11,13-tetramethyl-3,10,12,14,16,18,22,24-octaoxo-17-aza-2,5,8,11,14,17,20,23-octaazabicyclo[22.3.1]octacosa-1(27),4,6,9,12,24,26-heptaene-7-carboxylic acid, cyclic (7→24)-peptide; Aplidine (structural analog); Trididemnum solidum peptide; Marine tunicate cyclic depsipeptide
EINECS	Contact for details

Quality Control

Our Didemnins are supplied for research use under stringent quality protocols. Each batch is characterized and tested to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from advanced analytical techniques. We adhere to relevant quality management standards to support reliable and reproducible research outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details
Solubility	Soluble in DMSO, methanol; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.