Description

p-o-Desmethyl Verapamil is a key intermediate and metabolite in the synthesis and pharmacokinetic study of the calcium channel blocker Verapamil. This compound is of significant importance for pharmaceutical research and development, particularly in the investigation of drug metabolism, pharmacokinetics (DMPK), and the creation of analytical reference standards. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug development and bioanalytical method validation.

Application

• Pharmaceutical Intermediate: Critical synthetic building block in the production of Verapamil and its analogs.
• Metabolite Reference Standard: Used as an analytical standard in LC-MS, HPLC, and other chromatographic methods for quantifying Verapamil and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for understanding the metabolic pathways, clearance, and bioavailability of Verapamil.
• Impurity Profiling: Serves as a certified reference material (CRM) for identifying and controlling process-related impurities in Verapamil API manufacturing.
• Preclinical & Clinical Research: Supports toxicology studies and clinical trial bioanalysis for cardiovascular therapeutics.
• Method Development & Validation: Used to develop and validate robust analytical methods in compliance with ICH guidelines.

Basic Information

Product Name	p-o-Desmethyl Verapamil
CAS No.	77326-93-3
Molecular Formula	C26H38N2O4
Molecular Weight	442.60 g/mol
Synonyms	Norverapamil; D-617; 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile; 2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-isopropylpentanenitrile; Verapamil Metabolite I; Desmethylverapamil; N-Desmethyl Verapamil
EINECS	Contact for details

Quality Control

Our p-o-Desmethyl Verapamil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of specified impurities, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH Q3A/B guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.