Description

n-α-Carbobenzoxypyroglutamic Acid Chloromethyl Ketone is a specialized peptide synthesis reagent, specifically a chloromethyl ketone derivative, used as a potent and irreversible inhibitor of serine proteases. This compound matters for its high selectivity and reactivity, enabling precise biochemical research and the development of targeted therapeutic agents. It is primarily needed by pharmaceutical R&D laboratories, biochemical researchers, and fine chemical manufacturers engaged in protease inhibitor development and advanced peptide chemistry.

Application

• Protease Inhibitor Development: Serves as a key intermediate in the synthesis of potent, irreversible inhibitors for serine proteases like chymotrypsin, trypsin, and elastase.
• Biochemical Research: Used as an active site-directed affinity label to study enzyme mechanisms, active site structures, and protease function in biological pathways.
• Pharmaceutical Intermediate: A critical building block in the research and development of therapeutic agents targeting protease-related diseases, including inflammatory and cardiovascular conditions.
• Peptide Chemistry: Employed in advanced peptide synthesis for introducing specific functional groups or creating mechanism-based inhibitors.
• Diagnostic Reagent Synthesis: Used in the preparation of specialized reagents for diagnostic assays that detect or quantify protease activity.

Basic Information

Product Name	n-α-Carbobenzoxypyroglutamic Acid Chloromethyl Ketone
CAS No.	77319-02-9
Molecular Formula	C15H16ClNO6
Molecular Weight	341.75 g/mol
Synonyms	Z-Pyroglutamyl Chloromethyl Ketone; Cbz-Pyroglutamyl Chloromethyl Ketone; Z-Pyr-CMK; N-Carbobenzoxy-L-pyroglutamyl Chloromethyl Ketone; (S)-1-(((Benzyloxy)carbonyl)-5-oxopyrrolidine-2-carbonyl)chloromethane; 77319-02-9; Protease Inhibitor Z-Pyr-CMK
EINECS	Contact for details

Quality Control

Our n-α-Carbobenzoxypyroglutamic Acid Chloromethyl Ketone is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.