Description

Carboxyatractyloside is a potent, naturally occurring diterpenoid glycoside known for its specific inhibitory action on the mitochondrial adenine nucleotide translocator (ANT). This high-purity biochemical is critical for researchers investigating mitochondrial function, cellular energy metabolism, and apoptosis pathways. It serves as an essential tool compound for pharmaceutical R&D, academic institutions, and biotechnology companies focused on metabolic disorders, cardiology, and oncology research.

Application

• Biochemical Research: A key inhibitor used to study mitochondrial permeability transition pore (MPTP) function and the role of ANT in cellular bioenergetics.
• Pharmaceutical Development: Employed in target validation and screening assays for drug discovery programs targeting metabolic diseases and ischemia-reperfusion injury.
• Apoptosis Studies: Utilized as a research tool to induce and investigate mechanisms of programmed cell death in various cell lines.
• Toxicology: Serves as a reference standard in studies of plant-derived toxins and their effects on mitochondrial physiology.
• Academic & Institutional Research: Fundamental reagent for graduate and post-doctoral research in molecular biology, biochemistry, and cell biology departments.

Basic Information

Product Name	Carboxyatractyloside
CAS No.	77228-71-8
Molecular Formula	C31H44O16S2
Molecular Weight	736.8 g/mol
Synonyms	CATR; Carboxyatractyloside potassium salt; Atractyloside carboxylic acid; Gummiferin; 15-O-β-D-Glucopyranosyl-15-deoxyatractyligenin 2-O-sulfate 4-O-sulfate; Atractylis gummifera toxin (component); Adenine nucleotide translocator inhibitor
EINECS	Contact for details

Quality Control

Our Carboxyatractyloside CAS NO 77228-71-8 is manufactured under strict quality protocols suitable for research applications. Each batch is characterized and tested to ensure identity, purity, and biological activity. Certificates of Analysis (COA) detailing purity by HPLC, identity confirmation by spectroscopic methods (NMR, MS), and biological activity are provided with every shipment to guarantee traceability and consistency for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Biological Activity	Inhibits mitochondrial ADP/ATP transport (IC50 confirmed)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.