Description

3-Chloro-4,5-Difluorobenzotrifluoride is a high-value fluorinated aromatic building block characterized by its unique halogen and trifluoromethyl substitution pattern. This compound is essential for introducing specific steric and electronic properties into advanced molecular architectures. It is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorine-containing drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity, metabolic stability, and lipophilicity.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and thermal stability.
• Polymer & Resin Modifier: Imparts hydrophobicity, chemical resistance, and low surface energy properties when incorporated into specialty polymers and coatings.
• Organic Synthesis Building Block: Enables cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution due to the activated chlorine atom, facilitating diverse chemical transformations.

Basic Information

Product Name	3-Chloro-4,5-Difluorobenzotrifluoride
CAS No.	77227-99-7
Molecular Formula	C7H2ClF5
Molecular Weight	216.54 g/mol
Synonyms	1-Chloro-2,3-difluoro-4-(trifluoromethyl)benzene; 3-Chloro-4,5-difluoro-α,α,α-trifluorotoluene; 3-Chloro-α,α,α,4,5-pentafluorotoluene; 2,3-Difluoro-6-chlorobenzotrifluoride; Benzene, 1-chloro-2,3-difluoro-4-(trifluoromethyl)-; 4-(Trifluoromethyl)-3-chloro-1,2-difluorobenzene
EINECS	Contact for details

Quality Control

Our 3-Chloro-4,5-Difluorobenzotrifluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.1%
Density (at 20°C)	~1.55 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.