Description

3,5-Dichloro-4-Fluorobenzotrifluoride is a high-value fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring both chlorine and fluorine substituents on a trifluoromethylated benzene ring, makes it a critical intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and anti-infective therapies.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays.
• Functional Material Development: Employed in organic synthesis for creating specialty polymers, dyes, and electronic chemicals with specific optical or electronic properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.

Basic Information

Product Name	3,5-Dichloro-4-Fluorobenzotrifluoride
CAS No.	77227-81-7
Molecular Formula	C7H2Cl2F4
Molecular Weight	246.99 g/mol
Synonyms	1,3-Dichloro-2-fluoro-5-(trifluoromethyl)benzene; 2-Fluoro-α,α,α,3,5-pentachlorotoluene; 4-Fluoro-3,5-dichlorobenzotrifluoride; 3,5-Dichloro-4-fluorobenzylidene trifluoride; 3,5-Dichloro-α,α,α-trifluoro-p-fluorotoluene; Benzene, 1,3-dichloro-2-fluoro-5-(trifluoromethyl)-; 77227-81-7 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 3,5-Dichloro-4-Fluorobenzotrifluoride is produced under strict quality management protocols. We employ advanced analytical techniques including GC, HPLC, and NMR to ensure high purity and batch-to-batch consistency, meeting the stringent requirements of process chemistry and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (at 20°C)	~1.65 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.