Description

1Qn-Echinomycin is a potent, naturally occurring cyclic peptide antibiotic and bis-intercalator. This compound is of significant interest in biochemical and pharmacological research due to its unique ability to bind to specific DNA sequences and its potent antitumor activity. It serves as a critical research tool for scientists in oncology, molecular biology, and drug discovery, particularly for studying hypoxia-inducible factor (HIF-1) signaling pathways and developing novel cancer therapeutics.

Application

• Biochemical Research: Used as a specific inhibitor of HIF-1α (hypoxia-inducible factor 1-alpha) dimerization and DNA binding in cell-based assays and in vitro studies.
• Oncology & Cancer Research: Investigated for its potent antitumor and anti-angiogenic properties in preclinical models of various cancers.
• Molecular Biology: Employed as a DNA bis-intercalator to study DNA-protein interactions, chromatin structure, and gene expression regulation.
• Drug Discovery & Development: Serves as a lead compound or a pharmacological tool for developing novel chemotherapeutic agents targeting hypoxic tumor microenvironments.
• Academic & Pharmaceutical R&D: Essential for basic research in universities, research institutes, and pharmaceutical companies exploring hypoxia-related diseases.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	1Qn-Echinomycin
CAS No.	77195-99-4
Molecular Formula	C₅₀H₆₄N₁₂O₁₂S₂
Molecular Weight	1081.26 g/mol
Synonyms	Echinomycin; NSC-526417; Antibiotic X 14889A; Quinomycin A; Levomycin; BRN 0091133; B 589C; Compound 593A
EINECS	Contact for details

Quality Control

Every batch of 1Qn-Echinomycin is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and potency for research applications. A detailed Certificate of Analysis (COA) including HPLC purity, NMR, and MS data is supplied with each product to guarantee reproducible and reliable performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Ethanol; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.