Description

Benzyloxycarbonylalanyl-Alanyl-Proline Diazomethyl Ketone is a specialized, high-purity synthetic peptide derivative designed for advanced research and development. This compound serves as a critical building block and a potent, irreversible inhibitor for serine and cysteine proteases, enabling precise biochemical studies. It is essential for pharmaceutical researchers, medicinal chemists, and biochemists working in drug discovery, enzyme mechanism elucidation, and the development of novel therapeutic agents.

Application

• Protease Inhibitor Development: Acts as a key intermediate and active inhibitor scaffold in the design of drugs targeting enzymes like cathepsins, elastase, and other serine/cysteine proteases.
• Biochemical Research: Used as a tool compound to study enzyme kinetics, active site mapping, and inhibition mechanisms in academic and industrial laboratories.
• Medicinal Chemistry & Drug Discovery: Serves as a versatile building block for synthesizing more complex peptide-based inhibitors and potential therapeutic candidates.
• Pharmaceutical Intermediate: Employed in the synthesis of active pharmaceutical ingredients (APIs) for conditions involving dysregulated protease activity.
• Diagnostic Reagent Synthesis: Can be utilized in the development of enzyme-linked assays and diagnostic probes.

Basic Information

Product Name	Benzyloxycarbonylalanyl-Alanyl-Proline Diazomethyl Ketone
CAS No.	77180-12-2
Molecular Formula	C20H25N5O6
Molecular Weight	431.45 g/mol
Synonyms	Z-Ala-Ala-Pro-CHN2; Cbz-Ala-Ala-Pro-diazomethyl ketone; Z-Ala-Ala-Pro diazomethyl ketone; Ala-Ala-Pro Diazomethyl Ketone, N2-[(Benzyloxy)carbonyl]-; Acetylpeptide chloromethyl ketone analog; Protease Inhibitor Z-AAP-CHN2; Cathepsin Inhibitor; (S)-1-(((S)-1-(((S)-1-((Diazomethyl)amino)-1-oxopropan-2-yl)amino)-1-oxopropan-2-yl)amino)-3-((((benzyloxy)carbonyl)amino)methyl)-1-oxopropan-2-yl
EINECS	Contact for details

Quality Control

Our Benzyloxycarbonylalanyl-Alanyl-Proline Diazomethyl Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure stereochemical integrity. Certificates of Analysis (COA) with full traceability are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the container to reach room temperature in a dry atmosphere before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.