Description

Cholestane-3,7,12,25-Tetrol-3-Glucuronide is a high-purity conjugated bile acid derivative, specifically a glucuronidated tetrahydroxylated cholestane. This compound is of significant value as a critical reference standard and analytical reagent in biochemical and pharmaceutical research. It is primarily required by researchers and quality control laboratories in the pharmaceutical, diagnostic, and life science sectors for metabolic studies, method development, and calibration.

Application

• Pharmaceutical Reference Standard: Used for the identification, purity assessment, and quantification of related bile acids and their metabolites in drug development and quality control (QC/QA).
• Biochemical Research: Serves as a key substrate or intermediate in studies of bile acid metabolism, liver function, and glucuronidation pathways.
• Diagnostic Kit Development: Employed in the formulation and calibration of diagnostic assays and kits for liver and metabolic disorders.
• Metabolite Analysis: Acts as a critical standard in Liquid Chromatography-Mass Spectrometry (LC-MS) and High-Performance Liquid Chromatography (HPLC) methods for profiling complex biological samples.
• Enzymology Studies: Utilized to investigate the activity and kinetics of enzymes like UDP-glucuronosyltransferases (UGTs).

Basic Information

Product Name	Cholestane-3,7,12,25-Tetrol-3-Glucuronide
CAS No.	77172-80-6
Molecular Formula	C33H56O11
Molecular Weight	628.80 g/mol
Synonyms	3α,7α,12α,25-Tetrahydroxy-5β-cholestan-26-oic acid 3-β-D-glucuronide; 25-Hydroxycholic acid 3-glucuronide; 3-Glucuronide of cholestane-3,7,12,25-tetrol; 5β-Cholestane-3α,7α,12α,25-tetrol 3-β-D-glucuronide; (25R)-5β-Cholestane-3α,7α,12α,25-tetrol 3-β-D-glucopyranosiduronic acid
EINECS	Contact for details

Quality Control

Our Cholestane-3,7,12,25-Tetrol-3-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.