Description

Philanthotoxin 433 is a potent, naturally occurring neurotoxin and non-competitive antagonist of ionotropic glutamate receptors, specifically targeting AMPA and kainate receptors. This compound is a critical research tool for neuroscience and pharmacology, enabling the study of synaptic transmission, excitotoxicity, and neurological disorders. It is essential for academic researchers, pharmaceutical R&D teams, and diagnostic developers working on neurodegenerative disease models, pain research, and the development of novel neuroprotective agents.

Application

• Neuroscience Research: Used as a selective blocker to study the function and pharmacology of AMPA and kainate subtypes of glutamate receptors in neuronal circuits.
• Pharmacological Studies: Serves as a reference standard and tool compound for investigating excitatory synaptic transmission and receptor kinetics.
• Disease Modeling: Applied in research models of neurological conditions such as epilepsy, stroke (ischemia), and neurodegenerative diseases like Alzheimer's to understand excitotoxic mechanisms.
• Drug Discovery: Utilized in high-throughput screening (HTS) assays to identify and characterize potential antagonists or modulators of ionotropic glutamate receptors.
• Toxicology & Safety Pharmacology: Employed to assess the neurotoxic potential of other compounds or to study the protective effects of candidate neuroprotective drugs.
• Physiology & Cell Signaling: Aids in elucidating the role of glutamate receptors in learning, memory, and synaptic plasticity.

Basic Information

Product Name	Philanthotoxin 433
CAS No.	77108-00-0
Molecular Formula	C20H33N5O4
Molecular Weight	407.51 g/mol
Synonyms	PhTX-433; Philanthotoxin-433; N-[(4-Hydroxyphenyl)acetyl]-L-asparaginyl-1,5-diaminopentane; Argiotoxin-636; Glutamate receptor antagonist 433; Wasp toxin analogue 433; Non-competitive AMPA receptor antagonist
EINECS	Contact for details

Quality Control

Our Philanthotoxin 433 is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, MS, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, freezer environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 98% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.