Description

(-)-Mk-801 Maleate is a high-purity, enantiomerically pure chemical compound widely recognized for its potent and selective antagonistic activity at the N-methyl-D-aspartate (NMDA) receptor. This specificity makes it an indispensable research-grade biochemical for investigating neurological pathways and receptor functions. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuroscience, neuropharmacology, and the development of central nervous system (CNS) therapeutics.

Application

• Neuroscience Research: A critical tool for studying NMDA receptor physiology, excitotoxicity, and synaptic plasticity.
• Pharmacological Studies: Used as a reference standard in assays to screen and evaluate novel neuroprotective agents or CNS drug candidates.
• Biochemical Mechanism Investigation: Employed to elucidate the role of NMDA receptors in learning, memory, and neurological disorders.
• Academic & Institutional R&D: Serves as a key reagent in university and government research programs focused on neurology and psychiatry.
• Pharmaceutical Development: Used in preclinical research stages for target validation and proof-of-concept studies related to stroke, epilepsy, or neurodegenerative diseases.
• Reference Standard: Acts as a high-purity analytical standard for method development and quality control in related chemical synthesis.

Basic Information

Product Name	(-)-Mk-801 Maleate
CAS No.	77086-22-7
Molecular Formula	C16H15N . C4H4O4
Molecular Weight	337.37 g/mol
Synonyms	(-)-MK-801 Hydrogen Maleate; (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine Maleate; Dizocilpine Maleate; (5R,10S)-(+)-MK-801 Maleate; (5R,10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (Z)-2-Butenedioate; (-)-Dizocilpine Maleate
EINECS	Contact for details

Quality Control

Our (-)-Mk-801 Maleate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.