Description

Dizocilpine is a potent and selective non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, a critical target in neurological research. This high-purity compound is essential for investigating the mechanisms of excitatory neurotransmission, neurotoxicity, and conditions related to glutamate dysfunction. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and contract research organizations (CROs) focused on central nervous system disorders.

Application

• Neurological Research: A key pharmacological tool for studying NMDA receptor function, synaptic plasticity, and long-term potentiation (LTP).
• Neuroprotection Studies: Used in models of ischemic stroke, traumatic brain injury, and neurodegenerative diseases to examine excitotoxicity pathways.
• Psychiatric Disorder Models: Applied in preclinical research for schizophrenia, depression, and drug addiction due to its impact on glutamatergic signaling.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro assays to discover and characterize novel NMDA receptor modulators.

Basic Information

Product Name	Dizocilpine
CAS No.	77086-21-6
Molecular Formula	C16H15N
Molecular Weight	221.30 g/mol
Synonyms	MK-801; (+)-MK-801; (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine; Dizocilpine maleate; MK801
EINECS	Contact for details

Quality Control

Our Dizocilpine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.