Description

Hypothemycin is a potent and selective macrocyclic resorcylic acid lactone (RAL) natural product, widely recognized for its role as a specific inhibitor of mitogen-activated protein kinase kinases (MEKs). This compound is of significant interest in biochemical and pharmacological research for its ability to modulate key cellular signaling pathways. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for target validation, signal transduction studies, and as a lead compound in drug discovery.

Application

• Biochemical Research: A critical tool compound for studying the MEK/ERK signaling pathway and its role in cell proliferation, differentiation, and survival.
• Pharmaceutical Development: Serves as a reference standard and a lead structure in the discovery of novel kinase inhibitors for therapeutic applications, particularly in oncology.
• Cell Biology Studies: Used to investigate the effects of MEK inhibition on various cellular processes and disease models in vitro.
• Target Validation: Employed to confirm the biological role and therapeutic potential of MEK targets in preclinical research.
• Enzyme Inhibition Assays: Acts as a potent and selective inhibitor in high-throughput screening (HTS) and mechanistic studies of kinase activity.

Basic Information

Product Name	Hypothemycin
CAS No.	76958-67-3
Molecular Formula	C20H24O7
Molecular Weight	376.40 g/mol
Synonyms	(-)-Hypothemycin; L-783277; Antibiotic L-783277; (3R,5aR,6R,9aS,9bR)-6-Hydroxy-9b-methyl-2-oxo-3-[(E)-prop-1-enyl]-2,3,5a,6,7,8,9,9a-octahydro-5H-azuleno[4,5-b]furan-5-yl (2E)-2-methylbut-2-enoate; Zearalenone lactone derivative
EINECS	Contact for details

Quality Control

Our Hypothemycin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals to guarantee reliable and reproducible performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.