Description

Nafarelin Acetate CAS NO 76932-60-0 is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) with potent agonist activity. This compound is a critical active pharmaceutical ingredient (API) used in the development of advanced hormonal therapies. It is primarily required by pharmaceutical manufacturers and research institutions for the production of treatments for central precocious puberty, endometriosis, and certain hormone-responsive cancers.

Application

• Pharmaceutical API: Core active ingredient in injectable and nasal spray formulations for hormone therapy.
• Endometriosis Treatment: Used in medications to manage pain and symptoms associated with endometriosis.
• Central Precocious Puberty (CPP): Key component in therapies designed to delay early puberty in children.
• Oncology Research: Investigated for use in the treatment of prostate cancer, breast cancer, and other hormone-sensitive tumors.
• Assisted Reproductive Technology (ART): Employed in controlled ovarian stimulation protocols.
• Uterine Fibroids Management: Used in pre-surgical treatment to reduce fibroid size.
• Veterinary Pharmaceuticals: Applied in fertility control and treatment of reproductive disorders in animals.
• Biochemical Research: Serves as a high-purity reference standard and tool for studying GnRH receptor function.

Basic Information

Product Name	Nafarelin Acetate
CAS No.	76932-60-0
Molecular Formula	C66H83N17O13 • (C2H4O2)x
Molecular Weight	1322.5 g/mol (free base)
Synonyms	Nafarelin; Nafarelin Acetate Salt; (D-Nal(2)6)-LHRH; Gonadorelin (6-D-2-naphthylalanine) analog acetate; LHRH agonist (D-Nal-6); RS-94991; Synarel (Brand Name); SR-95228
EINECS	Contact for details

Quality Control

Our Nafarelin Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, chiral purity verification, and stringent controls for related substances and residual solvents to ensure compliance with pharmaceutical-grade standards. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Specific Rotation	-30° to -40° (c=1 in 1% acetic acid)
Amino Acid Ratio	Conforms to theoretical values
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 8.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Bacterial Endotoxins	< 10.0 EU/mg
Microbial Enumeration	Meets Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.