Description

Triacsin C is a potent and cell-permeable inhibitor of long-chain acyl-CoA synthetase (ACSL), a key enzyme in lipid metabolism. This compound is a critical research tool for studying fatty acid uptake, triglyceride synthesis, and lipid droplet formation in cellular models. It is essential for researchers in academic institutions, pharmaceutical R&D, and biotechnology companies investigating metabolic disorders, non-alcoholic fatty liver disease (NAFLD), and cancer metabolism.

Application

• Lipid Metabolism Research: Used to inhibit ACSL activity, allowing study of fatty acid activation and its role in cellular energy homeostasis.
• Metabolic Disease Modeling: A key reagent for creating in vitro models of steatosis (fatty liver) and insulin resistance.
• Cancer Biology Studies: Employed to investigate the dependency of certain cancer cells on de novo lipogenesis for proliferation and survival.
• Biochemical Assay Development: Serves as a reference standard and positive control in high-throughput screening (HTS) assays for ACSL inhibitors.
• Cell Signaling Pathways: Used to elucidate the links between lipid metabolism and inflammatory signaling pathways like NF-κB.
• Drug Discovery & Validation: A vital tool for target validation and mechanism-of-action studies for novel therapeutics targeting metabolic syndromes.

Basic Information

Product Name	Triacsin C
CAS No.	76896-80-5
Molecular Formula	C₂₄H₃₄N₄O₂
Molecular Weight	410.56 g/mol
Synonyms	Triacsin C; FR 190809; 1-Hydroxy-3-(E,E,E-2',4',7'-undecatrienylidine)triazene; ACSL Inhibitor III; Long-chain acyl-CoA synthetase inhibitor; (2E,4E,7E)-N-Hydroxy-2,4,7-undecatrienimidamide
EINECS	Contact for details

Quality Control

Our Triacsin C is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and structural confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and potency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Biological Activity (IC₅₀)	≤ 5 µM (ACSL inhibition in cell-based assay)
Solubility	Soluble in DMSO, ethanol; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.