Description

Arginine Chloromethyl Ketone is a specialized biochemical reagent and a potent, irreversible inhibitor of serine proteases. This compound is critical for researchers and manufacturers requiring precise enzyme activity control in complex biological systems. It is primarily utilized in pharmaceutical R&D, proteomics, and the development of therapeutic agents targeting coagulation and inflammatory pathways.

Application

• Protease Inhibition Research: Acts as a key tool compound for studying trypsin-like serine proteases, including thrombin, plasmin, and trypsin.
• Pharmaceutical Development: Serves as a lead structure or intermediate in the design of novel anticoagulant and anti-inflammatory drugs.
• Biochemical Assay Development: Used to validate assay specificity and to create controlled conditions in enzymatic studies.
• Proteomics & Cell Biology: Employed to selectively inhibit specific proteolytic pathways to understand protein function and cell signaling mechanisms.
• Diagnostic Reagent Manufacturing: Incorporated into the production of diagnostic kits that measure coagulation factors or other protease activities.

Basic Information

Product Name	Arginine Chloromethyl Ketone
CAS No.	76833-33-5
Molecular Formula	C9H18ClN5O2
Molecular Weight	263.73 g/mol
Synonyms	N-α-Benzoyl-L-arginine chloromethyl ketone; Bz-Arg-CH2Cl; Benzoyl-L-arginine chloromethyl ketone; TLCK; Tosyllysine chloromethyl ketone analog; L-1-Chloro-3-tosylamido-7-amino-2-heptanone (arginine variant); Protease Inhibitor TLCK analog; BACI
EINECS	Contact for details

Quality Control

Our Arginine Chloromethyl Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, identity confirmation by IR and NMR spectroscopy, and specific tests for residual solvents and moisture content. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under desiccant when not in use. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.