Description

Elastase-Cathepsin G Inhibitor CAS NO 76829-37-3 is a potent, dual-action serine protease inhibitor designed to target and neutralize the enzymatic activities of both human leukocyte elastase (HLE) and cathepsin G. This compound is critical for research and development in inflammatory and tissue remodeling pathways, offering a valuable tool for mechanistic studies and therapeutic target validation. It is primarily utilized by pharmaceutical researchers, biotech companies, and academic institutions focused on pulmonary diseases, autoimmune disorders, and cardiovascular research.

Application

• Biochemical Research: Used as a selective inhibitor to study the roles of elastase and cathepsin G in neutrophil-mediated inflammation and tissue degradation.
• Pharmaceutical Development: Serves as a key reference standard and lead compound in drug discovery programs targeting chronic obstructive pulmonary disease (COPD), cystic fibrosis, and emphysema.
• Inflammation Models: Applied in in vitro and in vivo models to elucidate protease-driven mechanisms in arthritis, atherosclerosis, and periodontitis.
• Diagnostic Assay Development: Utilized in the development and calibration of enzymatic activity assays and high-throughput screening (HTS) platforms.
• Protease Specificity Studies: Employed to determine inhibitor specificity profiles and kinetic parameters against related serine proteases.

Basic Information

Product Name	Elastase-Cathepsin G Inhibitor
CAS No.	76829-37-3
Molecular Formula	C20H29N5O4
Molecular Weight	403.48 g/mol
Synonyms	N-[[(Phenylmethoxy)carbonyl]-L-valyl]-N-[(2S)-4-methyl-1-[[(2S)-1-[(2S,3S)-2-methyl-1-oxo-3-pentyl]azetidin-2-yl]carbonyl]-2-pyrrolidinyl]-L-prolinamide; Z-Val-Pro-Val-Azetidine(2S,3S)-AHA; Dual Elastase/Cathepsin G Inhibitor; HLE/Cath G Inhibitor; MeOSuc-AAPV-CMK (related chloromethylketone analog); Serine Protease Inhibitor (Elastase/Cathepsin G).
EINECS	Contact for details

Quality Control

Our Elastase-Cathepsin G Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and biological activity assays to ensure potency and specificity. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee consistent quality and traceability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Biological Activity (IC50)	Reported per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.