Description

Calcimycin Hemicalcium Salt is a specialized calcium complex of the potent ionophore antibiotic calcimycin (A23187). This compound is crucial for research and development in cellular physiology and biochemistry, where it serves as a highly effective tool for selectively transporting divalent cations, particularly calcium ions, across biological membranes. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in studies of calcium signaling, cell apoptosis, and mitochondrial function.

Application

• Biochemical Research: As a selective calcium ionophore to manipulate intracellular calcium concentrations in cell culture and in vitro studies.
• Pharmacology & Drug Discovery: Used in screening assays to study calcium-dependent pathways, enzyme activation, and receptor function.
• Cell Biology: A key tool for inducing programmed cell death (apoptosis) and studying mitochondrial permeability transition.
• Immunology Research: Employed to study calcium flux in immune cells such as lymphocytes and mast cells.
• Neuroscience: Used in research on neurotransmitter release and neuronal signaling mechanisms that are calcium-dependent.
• Reference Standard: Serves as a high-purity analytical standard for quality control in pharmaceutical development.

Basic Information

Product Name	Calcimycin Hemicalcium Salt
CAS No.	76822-16-7
Molecular Formula	C₂₉H₃₆CaN₂O₆ • ½H₂O
Molecular Weight	Approx. 549.65 g/mol (Anhydrous basis)
Synonyms	A23187 Hemicalcium Salt; Calcimycin Calcium Salt; Antibiotic A23187 Hemicalcium Salt; Calcium Ionophore A23187 Hemicalcium; 4-Bromo-A23187 Hemicalcium Salt; (2S,3S,5R,6S,8R,9R,11E)-5-Methyl-6-[(1R,2R,3S,5R)-1,2,3,5-tetramethyl-4-oxoheptyl]-2,3,8,9-tetrahydro-8,9-epoxy-2,3-dimethyl-1,7-dioxaspiro[5.5]undec-11-en-4-one Hemicalcium Salt
EINECS	Contact for details

Quality Control

Our Calcimycin Hemicalcium Salt is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and storage under inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.