Description

Thyrotropin Releasing Hormone Chloromethyl Ketone is a synthetic peptide derivative and a potent, irreversible active-site-directed inhibitor of serine proteases, particularly those involved in prohormone processing. This compound is of significant value in biochemical and pharmaceutical research for its ability to selectively inhibit key enzymes, enabling the study of hormone biosynthesis and regulation pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on neuroendocrinology, protease function, and therapeutic target validation.

Application

• Biochemical Research: As a specific inhibitor for studying the enzymatic processing of thyrotropin-releasing hormone (TRH) and related neuropeptides.
• Protease Mechanism Studies: Used to investigate the structure, function, and inhibition kinetics of serine proteases like prohormone convertases.
• Pharmaceutical Development: Serves as a key reference standard and tool compound in drug discovery programs targeting hormonal disorders and protease-related diseases.
• Diagnostic Reagent Manufacturing: Employed in the development of enzyme-linked immunosorbent assays (ELISAs) and other diagnostic kits for endocrine research.
• Academic Research: Utilized in university and institutional labs for fundamental studies in neuroendocrinology and peptide metabolism.

Basic Information

Product Name	Thyrotropin Releasing Hormone Chloromethyl Ketone
CAS No.	76819-95-9
Molecular Formula	C16H21N5O4Cl
Molecular Weight	382.82 g/mol
Synonyms	TRH Chloromethyl Ketone; Pyroglutamyl-Histidyl-Proline Amide Chloromethyl Ketone; pGlu-His-Pro-NH2 Chloromethyl Ketone; Thyroliberin Chloromethyl Ketone; Protease Inhibitor 76819-95-9; L-Pyroglutamyl-L-histidyl-L-prolinamide Chloromethyl Ketone; (S)-5-Oxo-1-(1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)-2-(3-(2-(chloromethyl)ketone)propyl)imidazolium
EINECS	Contact for details

Quality Control

Our Thyrotropin Releasing Hormone Chloromethyl Ketone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.