Description

Thyrotropin Releasing Hormone Diazomethyl Ketone is a specialized synthetic peptide derivative designed for advanced biochemical and pharmaceutical research. This compound serves as a critical tool compound and synthetic intermediate, particularly valued for its role in studying enzyme inhibition and hormone signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on neuroendocrinology and protease research.

Application

• Biochemical Research: Used as a potent and specific inhibitor for studying the activity and mechanism of cysteine proteases and other enzymes.
• Pharmaceutical Development: Serves as a key intermediate in the synthesis of novel peptide-based therapeutics and diagnostic agents targeting the hypothalamic-pituitary-thyroid axis.
• Neuroendocrine Studies: Employed in laboratory investigations to modulate Thyrotropin-Releasing Hormone (TRH) pathways and understand related physiological processes.
• Protease Profiling: Acts as an active site-directed affinity label for the characterization and identification of specific protease families in complex biological samples.
• Academic Research: Utilized in university and institutional labs for fundamental studies in peptide chemistry, medicinal chemistry, and molecular biology.
• Reference Standard: Provides a high-purity compound for use as an analytical standard in quality control and method development for related pharmaceutical products.

Basic Information

Product Name	Thyrotropin Releasing Hormone Diazomethyl Ketone
CAS No.	76760-06-0
Molecular Formula	C18H24N6O5
Molecular Weight	404.42 g/mol
Synonyms	TRH Diazomethyl Ketone; Thyroliberin Diazomethyl Ketone; Pyroglutamyl-histidyl-prolinamide Diazomethyl Ketone; L-Pyroglutamyl-L-histidyl-L-prolinamide Diazomethyl Ketone; (S)-5-Oxo-1-((S)-1-((S)-2-((diazomethyl)amino)-2-oxo-1-(1H-imidazol-4-yl)ethylamino)-1-oxopropan-2-yl)pyrrolidine-2-carboxamide; Protease Inhibitor TRH-DMK; Affinity Label for Cysteine Proteases
EINECS	Contact for details

Quality Control

Our Thyrotropin Releasing Hormone Diazomethyl Ketone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and NMR for structural verification, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere after each use and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.