Description

Cytidine, 5'-(Hydrogen 4-Morpholinylphosphonate) is a chemically modified nucleoside analog where the 5'-hydroxyl group of cytidine is replaced by a hydrogen 4-morpholinylphosphonate moiety. This modification is critical for imparting unique biochemical properties, making it a valuable intermediate in the synthesis of nucleotide prodrugs and antiviral agents. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing novel therapeutic compounds, particularly in the fields of virology and oncology.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleotide analogs and prodrugs for antiviral and anticancer therapies.
• Antiviral Research: Used in the development of compounds targeting viral polymerases, such as those for hepatitis C (HCV) and other RNA viruses.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic studies to understand nucleotide metabolism and signaling pathways.
• Prodrug Development: The phosphonate moiety is instrumental in creating membrane-permeable prodrugs that enhance cellular uptake and bioavailability.
• Chemical Biology: Utilized in the synthesis of labeled nucleotides for diagnostic assays and molecular probe development.
• Fine Chemical Synthesis: Acts as a specialized intermediate for custom synthesis services catering to the life sciences industry.

Basic Information

Product Name	Cytidine, 5'-(Hydrogen 4-Morpholinylphosphonate)
CAS No.	76742-17-1
Molecular Formula	C13H21N4O8P
Molecular Weight	392.31 g/mol
Synonyms	5'-Deoxy-5'-(4-morpholinylphosphinyl)cytidine; Cytidine 5'-(hydrogen 4-morpholinylphosphonate); 4-Morpholinephosphonic acid P'-[5-deoxy-β-D-ribofuranos-5-yl] ester, cytosine-1-yl; 1-(5-O-[(4-Morpholinylphosphinyl)oxy]-β-D-ribofuranosyl)cytosine; 5'-O-[(4-Morpholinyl)hydroxyphosphinyl]cytidine; Cytidine 5'-morpholinophosphonate; 5'-Morpholinophosphonylcytidine
EINECS	Contact for details

Quality Control

Our production of Cytidine, 5'-(Hydrogen 4-Morpholinylphosphonate) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements. Our quality system is designed to meet the exacting standards of the global pharmaceutical supply chain.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.