Description

(5Z,7E,23R)-3β,23,25-Trihydroxy-9,10-Secocholesta-5,7,10(19)-Trien-26-Oic Acid γ-Lactone is a high-purity, synthetic vitamin D analog and a key intermediate in the production of advanced pharmaceutical compounds. This compound matters for its critical role in the synthesis of calcitriol derivatives and other therapeutic agents targeting vitamin D receptor pathways. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the development of treatments for osteoporosis, psoriasis, and secondary hyperparathyroidism.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) like calcitriol, paricalcitol, and other vitamin D analogs.
• Research & Development: Used in biochemical and pharmacological research to study vitamin D metabolism, receptor binding, and signaling pathways.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Studies: Employed in the development of new therapeutic candidates for bone disorders, autoimmune diseases, and certain cancers.
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for vitamin D-related pharmaceuticals under cGMP conditions.

Basic Information

Product Name	(5Z,7E,23R)-3β,23,25-Trihydroxy-9,10-Secocholesta-5,7,10(19)-Trien-26-Oic Acid γ-Lactone
CAS No.	76741-54-3
Molecular Formula	C27H40O5
Molecular Weight	444.61 g/mol
Synonyms	1α,25-Dihydroxy-26,23-lactone-vitamin D3; (23R)-25-Deoxy-1α-hydroxy-26,23-lactone-24-oxovitamin D3; 1α-Hydroxy-26,23-lactone-24-oxovitamin D3; 1α,25-Dihydroxyvitamin D3-26,23-lactone; Calcitriol Lactone Intermediate; Paricalcitol Intermediate; ZK 191784; ZK-191784
EINECS	Contact for details

Quality Control

Our (5Z,7E,23R)-3β,23,25-Trihydroxy-9,10-Secocholesta-5,7,10(19)-Trien-26-Oic Acid γ-Lactone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.