Description

Dl-Thiorphan CAS NO 76721-89-6 is a synthetic, racemic mixture of the potent and selective enkephalinase inhibitor, thiorphan. This compound is of significant interest in biochemical and pharmacological research due to its role in modulating endogenous opioid peptide activity. It serves as a critical research chemical for scientists and developers in the pharmaceutical and life sciences sectors, particularly those investigating neurobiology, pain management pathways, and enzyme inhibition mechanisms.

Application

• Biochemical Research: Used as a standard and tool compound in studies of enkephalin-degrading enzymes (neprilysin).
• Pharmacological Studies: Critical for investigating the physiological roles of endogenous enkephalins in pain modulation, mood, and addiction.
• Drug Discovery & Development: Acts as a reference molecule and lead compound for developing novel analgesic and neuroprotective agents.
• Neuroscience Research: Employed in experimental models to understand the interaction between the opioid and other neurotransmitter systems.
• Enzyme Inhibition Assays: Serves as a potent, selective inhibitor in enzymatic activity tests and high-throughput screening (HTS) platforms.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in neurochemistry and molecular biology.

Basic Information

Product Name	Dl-Thiorphan
CAS No.	76721-89-6
Molecular Formula	C13H18NO4S
Molecular Weight	284.35 g/mol
Synonyms	N-[(R,S)-2-(Mercaptomethyl)-1-oxo-3-phenylpropyl]glycine; (±)-Thiorphan; DL-Thiorphan; Racemic Thiorphan; NSC 326023; Enkephalinase Inhibitor; (RS)-Thiorphan; 2-[(2-Mercaptomethyl)-1-oxo-3-phenylpropyl]aminoacetic acid
EINECS	Contact for details

Quality Control

Our Dl-Thiorphan is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. We provide comprehensive analytical data, including HPLC purity, chiral purity, and identity confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is supplied with every batch to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Racemic mixture (approx. 50:50)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.