Description

Tunicamycin B3 CAS NO 76544-50-8 is a specific congener of the tunicamycin family of nucleoside antibiotics, characterized by its potent inhibitory activity against N-linked glycosylation. This compound is a critical research tool for studying protein processing, secretion, and the unfolded protein response in eukaryotic cells. It is essential for researchers and developers in the fields of cell biology, biochemistry, and pharmaceutical development, particularly for investigating metabolic pathways and potential therapeutic targets.

Application

• Biochemical Research: A fundamental tool for inhibiting N-linked glycosylation to study protein folding, trafficking, and secretion in cell culture models.
• Cancer Research: Used to induce endoplasmic reticulum (ER) stress and activate the unfolded protein response (UPR) in studies of apoptosis and tumor biology.
• Virology Studies: Employed to investigate the role of glycosylation in viral envelope protein processing and infectivity.
• Antibiotic Mechanism Studies: Serves as a reference standard in research exploring the biosynthesis of bacterial cell walls and novel antibiotic targets.
• Pharmaceutical Screening: Used in high-throughput assays to identify compounds that modulate ER stress pathways or glycosylation inhibitors.
• Academic & Industrial R&D: Critical reagent for basic scientific discovery and applied research in biotechnology and drug development pipelines.

Basic Information

Product Name	Tunicamycin B3
CAS No.	76544-50-8
Molecular Formula	C39H64N4O16
Molecular Weight	844.95 g/mol
Synonyms	Tunicamycin B3; Antibiotic Tunicamycin B3; Tunicamycin V; Tunicamycin Homolog B3; NSC 369010; 1-Deoxynojirimycin Tunicaminyluracil Derivative; Streptomyces lysosuperificus Antibiotic B3
EINECS	Contact for details

Quality Control

Our Tunicamycin B3 is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Biological Activity	Inhibits protein glycosylation in cell-based assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.