Description

Tunicamycin A2 Homolog is a specific structural variant of the tunicamycin family of nucleoside antibiotics, characterized by its CAS number 76544-45-1. This compound is a potent and selective inhibitor of N-linked glycosylation, serving as a critical research tool for studying protein processing, endoplasmic reticulum (ER) stress, and the unfolded protein response (UPR) in eukaryotic cells. It is essential for researchers and developers in pharmaceutical discovery, molecular biology, and biochemistry who require high-purity biochemical reagents for mechanistic studies and pathway validation.

Application

• Biochemical Research: Used as a standard inhibitor to block protein N-glycosylation, inducing ER stress in cell culture models.
• Cancer Research: Investigated for its role in sensitizing cancer cells to apoptosis by disrupting protein folding and cellular homeostasis.
• Antiviral Studies: Applied in research to understand viral replication mechanisms that depend on host cell glycosylation pathways.
• Neuroscience: Utilized in models of neurodegenerative diseases to study ER stress-related neuronal cell death.
• Antibiotic Mechanism Studies: Serves as a reference compound for studying the biosynthesis of bacterial cell walls and the action of nucleoside antibiotics.
• Cell Line Development: Employed in selection protocols for generating glycosylation-deficient mutant cell lines.

Basic Information

Item	Details
Product Name	Tunicamycin A2 Homolog
CAS No.	76544-45-1
Molecular Formula	C39H64N4O16
Molecular Weight	844.95 g/mol
Synonyms	Tunicamycin A2; Antibiotic Tunicamycin A2; Tunicamycin A2 (Streptomyces lysosuperificus); Tunicamycin V; NSC 177382; 2-[(2R,3R,4S,5S,6R)-4-[(2S,3S,4S,5R,6R)-5-[(2R,3S,4S,5S,6R)-3,4-Dihydroxy-6-methyl-5-(methylamino)oxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]-1-[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]pyrimidine-2,4-dione
EINECS	Contact for details

Quality Control

Our Tunicamycin A2 Homolog is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the exacting standards required for life science research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Biological Activity	Inhibits protein N-glycosylation in cell-based assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.