Description

3-[Chloro(Difluoro)Methyl]Pyridine is a versatile halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a reactive chlorodifluoromethyl group attached to the pyridine ring, makes it a valuable precursor for introducing fluorinated motifs into target molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the manufacture of advanced pesticides and herbicides, where the fluorinated moiety can improve metabolic stability, bioavailability, and binding affinity.
• Material Science Precursor: Acts as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and electronic materials requiring fluorinated aromatic units.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to construct complex biaryl systems for various applications.
• Fluorine Chemistry Research: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and creating fluorinated compound libraries.

Basic Information

Product Name	3-[Chloro(Difluoro)Methyl]Pyridine
CAS No.	76541-43-0
Molecular Formula	C7H6ClF2N
Molecular Weight	177.58 g/mol
Synonyms	3-(Chlorodifluoromethyl)pyridine; Pyridine, 3-[(chlorodifluoro)methyl]-; 3-(Chloro-difluoro-methyl)-pyridine; 3-Pyridylchlorodifluoromethane; 3-Chlorodifluoromethylpyridine; α,α-Difluoro-α-chloro-3-picoline
EINECS	Contact for details

Quality Control

Our 3-[Chloro(Difluoro)Methyl]Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider maintaining under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.