Description

Azamulin is a potent and selective inhibitor of the proteasome, a key regulatory complex in cellular protein degradation. This compound is a critical research tool for studying proteasome function, ubiquitin-proteasome pathway signaling, and related disease mechanisms. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, immunology, and neurodegenerative disease research. Azamulin CAS NO 76530-44-4 offers high biological activity for investigating novel therapeutic targets.

Application

• Biochemical Research: A fundamental tool for in vitro and cell-based studies of proteasome activity and inhibition kinetics.
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in high-throughput screening and target validation for cancer and inflammatory diseases.
• Mechanistic Studies: Enables investigation of protein turnover, cell cycle regulation, and apoptosis signaling pathways dependent on proteasome function.
• Academic Research: Supports basic science research in molecular biology, biochemistry, and cellular physiology to understand disease etiology.
• Biomarker Research: Assists in studies exploring proteasome activity as a potential biomarker for disease progression or treatment response.

Basic Information

Product Name	Azamulin
CAS No.	76530-44-4
Molecular Formula	C20H25N5O4S
Molecular Weight	431.51 g/mol
Synonyms	Azamulin; MG-132; Carbobenzoxy-Leu-Leu-leucinal; Z-LLL-CHO; Z-Leu-Leu-Leu-al; N-[(2S,3R)-3-Hydroxy-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-oxo-3-phenyl-1-[[(phenylmethoxy)carbonyl]amino]propan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]-L-phenylalaninamide; Proteasome Inhibitor MG132; Z-Leu-Leu-Leu-H
EINECS	Contact for details

Quality Control

Our Azamulin is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity confirmation and identity verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your critical review. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.