Description

Phorbol-12-Decanoate is a specific ester derivative of the phorbol diterpene core, a class of compounds known for their potent biological activity. This high-purity reference standard is critical for pharmaceutical and biochemical research, particularly in the study of protein kinase C (PKC) signaling pathways. It is primarily utilized by research institutions and pharmaceutical developers focused on oncology, inflammation, and cell biology.

Application

• Biochemical Research: As a potent activator of Protein Kinase C (PKC) isoforms for studying intracellular signal transduction mechanisms.
• Pharmacological Studies: Used in vitro to investigate the role of PKC in cancer cell proliferation, tumor promotion, and apoptosis.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Academic Research: A key tool in university and institutional labs for fundamental research in cell biology and molecular pharmacology.
• Drug Discovery Screening: Employed in high-throughput screening assays to identify novel PKC inhibitors or modulators.
• Toxicology Studies: Used as a model compound to study the biochemical effects of phorbol esters and related tumor promoters.

Basic Information

Product Name	Phorbol-12-Decanoate
CAS No.	76423-68-2
Molecular Formula	C30H44O8
Molecular Weight	532.67 g/mol
Synonyms	12-O-Decanoylphorbol 13-acetate; 12-Decanoylphorbol 13-acetate; PDBu analogue; Phorbol 12-decanoate 13-acetate; NSC 326322; 4,9,12-beta,13-alpha,20-Pentahydroxytiglia-1,6-dien-3-one 12-decanoate 13-acetate
EINECS	Contact for details

Quality Control

Our Phorbol-12-Decanoate is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to the specified grade.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.