Description

4-Borono-L-Phenylalanine is a boron-containing derivative of the essential amino acid L-phenylalanine, serving as a critical building block in modern pharmaceutical and diagnostic research. Its unique structure, featuring a boronic acid functional group, makes it a key intermediate for the synthesis of targeted therapeutics and advanced imaging agents. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and radiopharmaceutical sectors, particularly in the development of Boron Neutron Capture Therapy (BNCT) agents and Positron Emission Tomography (PET) tracers.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially for targeted cancer therapies.
• Boron Neutron Capture Therapy (BNCT): Serves as a key component in the development of boron delivery agents for this advanced cancer treatment modality.
• Radiopharmaceuticals: Used in the research and production of PET (Positron Emission Tomography) imaging agents, such as [18F]FBPA, for tumor diagnostics.
• Bioconjugation & Probe Development: Enables the labeling of peptides, proteins, and antibodies for biochemical research and diagnostic assays.
• Chemical Biology Research: Acts as a tool compound for studying enzyme inhibition, metabolic pathways, and amino acid transport mechanisms.
• Advanced Material Synthesis: A building block for creating novel boron-based polymers or sensors with specific molecular recognition properties.

Basic Information

Product Name	4-Borono-L-Phenylalanine
CAS No.	76410-58-7
Molecular Formula	C9H12BNO4
Molecular Weight	209.01 g/mol
Synonyms	L-4-Boronophenylalanine; BPA; L-BPA; 4-Borono-L-phenylalanine; (S)-2-Amino-3-(4-boronophenyl)propanoic acid; Borofalan; FBPA; 4-Dihydroxyboryl-L-phenylalanine; NSC 113223
EINECS	Contact for details

Quality Control

Our 4-Borono-L-Phenylalanine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm the L-configuration, and specific tests for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.