Description

5-Diethylamino-Naphthalene-1-Sulfonyl Chloride is a specialized sulfonyl chloride derivative that serves as a critical building block for the synthesis of fluorescent probes and labeling reagents. Its core value lies in its ability to react with amines and other nucleophiles to form stable, highly fluorescent dansyl derivatives, which are essential tools in analytical chemistry and life sciences research. This compound is primarily needed by manufacturers and research institutions in the pharmaceutical, biotechnology, and diagnostic sectors for developing sensitive detection assays and advanced molecular probes.

Application

• Fluorescent Labeling Reagent: Used to tag proteins, peptides, amino acids, and other biomolecules for detection and quantification via fluorescence spectroscopy or microscopy.
• Dansyl Chloride Derivative Synthesis: Acts as the key precursor for synthesizing various dansylamide and dansylhydrazine derivatives, which are common fluorescent tags.
• Analytical Chemistry Standards: Employed in the preparation of internal standards and reference compounds for High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS) methods.
• Proteomics & Biochemical Research: Utilized in studying protein structure, function, and interactions through fluorescence labeling techniques.
• Diagnostic Kit Manufacturing: Incorporated into the development of fluorescent immunoassays and other diagnostic test kits that require high-sensitivity detection.
• Material Science: Potential use in creating fluorescent sensors and functional materials for chemical detection.

Basic Information

Product Name	5-Diethylamino-Naphthalene-1-Sulfonyl Chloride
CAS No.	76264-86-3
Molecular Formula	C₁₄H₁₆ClNO₂S
Molecular Weight	297.80 g/mol
Synonyms	5-(Diethylamino)naphthalene-1-sulfonyl chloride; Dansyl chloride; 1-Dimethylaminonaphthalene-5-sulfonyl chloride (common misnomer); DENS-Cl; DNSC; 5-(N,N-Diethylamino)-1-naphthalenesulfonyl chloride; 1-Naphthalenesulfonyl chloride, 5-(diethylamino)-; N,N-Diethyl-5-naphthylamine-1-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 5-Diethylamino-Naphthalene-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flame, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.