Description

Herbimycin B is a benzoquinone ansamycin antibiotic and a potent, selective inhibitor of Hsp90 (Heat Shock Protein 90). This compound matters as a critical research tool for studying cellular signaling pathways, protein folding, and chaperone function in oncology and neurodegenerative disease research. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cancer biology, molecular chaperone studies, and drug discovery.

Application

• Biomedical Research: Used as a specific Hsp90 inhibitor to study its role in protein homeostasis, client protein degradation, and signal transduction pathways.
• Oncology Studies: Employed in cancer research to investigate mechanisms of tumor cell survival, proliferation, and the potential of Hsp90 as a therapeutic target.
• Neurodegenerative Disease Models: Applied in research models for Alzheimer's, Parkinson's, and Huntington's disease to explore protein aggregation and chaperone-mediated protection.
• Signal Transduction Analysis: A key reagent for dissecting kinase-dependent signaling cascades, particularly those involving Src-family kinases, due to its inhibitory activity.
• Antibiotic Mechanism Studies: Serves as a reference compound in studies of ansamycin-class antibiotics and their biological activities.
• Cell Culture & In Vitro Assays: Utilized in cell-based assays to induce specific pharmacological responses related to Hsp90 inhibition.

Basic Information

Product Name	Herbimycin B
CAS No.	76207-83-5
Molecular Formula	C30H42N2O9
Molecular Weight	574.67 g/mol
Synonyms	Herbimycin B; Antibiotic Herbimycin B; Ansamycin Herbimycin B; 15-Demethoxy-17-demethoxy-17-aminogeldanamycin; NSC 305978; L-588,833; Benzoquinoid ansamycin antibiotic; Hsp90 Inhibitor Herbimycin B
EINECS	Contact for details

Quality Control

Our Herbimycin B is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to Orange Powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to Reference Spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.