Description

Tcpobop is a high-purity chemical compound, identified by CAS No. 76150-91-9, that serves as a potent and selective agonist for the constitutive androstane receptor (CAR). This compound is a critical research tool for studying xenobiotic metabolism, liver gene regulation, and hepatocyte proliferation. It is primarily utilized by pharmaceutical researchers, toxicologists, and academic institutions engaged in drug metabolism studies, hepatotoxicity assessment, and nuclear receptor signaling pathway analysis.

Application

• Pharmacological Research: Used as a potent agonist to activate the constitutive androstane receptor (CAR) in in vitro and in vivo studies.
• Drug Metabolism & Toxicology: A key tool for inducing cytochrome P450 enzymes (notably CYP2B and CYP3A) to study drug-drug interactions and metabolic pathways.
• Hepatology Studies: Employed in research on liver hypertrophy, hepatocyte proliferation, and chemical-induced hepatocarcinogenesis.
• Gene Regulation Analysis: Facilitates the investigation of CAR-mediated transcriptional regulation of genes involved in detoxification and energy metabolism.
• Biomarker Discovery: Used in preclinical models to identify and validate biomarkers associated with CAR activation.
• Reference Standard: Serves as a high-purity analytical standard for method development and validation in bioanalytical laboratories.

Basic Information

Product Name	Tcpobop
CAS No.	76150-91-9
Molecular Formula	C17H16Cl3NO2
Molecular Weight	372.67 g/mol
Synonyms	1,4-Bis[2-(3,5-Dichloropyridyloxy)]benzene; TCPOBOP; 4-(1,1,1-Trichloro-2-methylpropyl)-2,6-dichlorophenyl methylcarbamate; TCBOBOP; CAR Agonist; CAR Ligand; 3,3',5,5'-Tetrachloro-1,4-bis(pyridyloxy)benzene
EINECS	Contact for details

Quality Control

Our Tcpobop is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation, identity verification by IR and NMR spectroscopy, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.