Description

(3A,5B,7A,12A)-23-Carboxy-7,12-Dihydroxy-24-Norcholan-3-Yl B-D-Glucopyranosiduronic Acid CAS NO 76060-22-5 is a high-purity, conjugated bile acid derivative, specifically a glucuronide conjugate, which is critical for advanced research and development in metabolic pathways. This compound serves as a valuable reference standard and synthetic intermediate for pharmaceutical and biochemical applications. It is primarily utilized by researchers and manufacturers in the life sciences sector focusing on hepatobiliary function, drug metabolism studies, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and qualification of bile acid metabolites in analytical methods development and validation.
• Drug Metabolism & Pharmacokinetics (DMPK) Research: Essential for studying Phase II metabolism (glucuronidation) pathways, enzyme kinetics, and transporter interactions in preclinical models.
• Biochemical Research: Serves as a substrate or inhibitor in enzymatic assays to investigate the function of UDP-glucuronosyltransferases (UGTs) and other metabolic enzymes.
• Diagnostic Reagent Development: Employed in the formulation of calibrators and controls for in-vitro diagnostic (IVD) kits targeting liver function and metabolic disorders.
• Synthetic Intermediate: Acts as a key building block for the chemical synthesis of more complex bile acid analogs and prodrugs with targeted therapeutic properties.
• Academic Research: Supports fundamental studies in gastroenterology, hepatology, and cholesterol metabolism at universities and research institutes.

Basic Information

Product Name	(3A,5B,7A,12A)-23-Carboxy-7,12-Dihydroxy-24-Norcholan-3-Yl B-D-Glucopyranosiduronic Acid
CAS No.	76060-22-5
Molecular Formula	C31H48O12
Molecular Weight	612.71 g/mol
Synonyms	7,12-Dihydroxy-3-(β-D-glucopyranuronosyloxy)-24-nor-5β-cholan-23-oic Acid; Norcholanic Acid Glucuronide; 3α-Glucuronyl-7α,12α-dihydroxy-5β-nor-23-cholanoic Acid; Tauro-7α,12α-dihydroxy-5β-cholan-24-oic Acid 3-O-β-D-glucuronide (related); Bile Acid Glucuronide Conjugate; 3α-(β-D-Glucopyranosiduronic acid)-7α,12α-dihydroxy-5β-norcholan-23-oic Acid; 24-Nor-5β-cholan-23-oic acid, 7,12-dihydroxy-3-(β-D-glucopyranuronosyloxy)-, (3α,5β,7α,12α)-
EINECS	Contact for details

Quality Control

Our (3A,5B,7A,12A)-23-Carboxy-7,12-Dihydroxy-24-Norcholan-3-Yl B-D-Glucopyranosiduronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For prolonged storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.