Description

4-(Methylnitrosamino)-1-(3-Pyridyl-n-Oxide)-1-Butanone is a nitrosamine derivative of significant interest in biochemical and toxicological research. This compound is crucial for scientists investigating the metabolic activation and carcinogenic mechanisms of tobacco-specific nitrosamines. It is primarily required by research institutions, analytical laboratories, and pharmaceutical companies focused on oncology, toxicology, and chemical safety assessment. Our supply ensures high-purity material essential for generating reliable and reproducible experimental data.

Application

• Biochemical Research: Used as a reference standard and active agent in studies exploring the carcinogenic pathways of tobacco-specific nitrosamines (TSNAs).
• Analytical Standard: Serves as a critical calibration standard in advanced analytical techniques like LC-MS/MS and GC-MS for the quantification of nitrosamine impurities.
• Toxicology Studies: Employed in in vitro and in vivo models to assess genotoxicity, DNA adduct formation, and organ-specific carcinogenesis.
• Pharmaceutical Impurity Testing: Acts as a representative nitrosamine compound for developing and validating analytical methods to detect and control nitrosamine impurities (e.g., NDMA, NDEA) in active pharmaceutical ingredients (APIs) and drug products, supporting compliance with regulatory guidelines (e.g., FDA, EMA).
• Chemical Reference Material: Provides a well-characterized compound for spectroscopic and chromatographic method development in quality control laboratories.

Basic Information

Product Name	4-(Methylnitrosamino)-1-(3-Pyridyl-n-Oxide)-1-Butanone
CAS No.	76014-82-9
Molecular Formula	C10H13N3O2
Molecular Weight	207.23 g/mol
Synonyms	4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone N-Oxide; NNK N-Oxide; 4-(N-Methyl-N-nitrosamino)-1-(3-pyridyl-N-oxide)-1-butanone; (4-Oxo-4-(3-pyridyl-N-oxide)butyl)methylnitrosamine; NNK N-Oxide; 4-(Methylnitrosamino)-1-(3-pyridyl-N-oxide)-1-butanone; Tobacco-Specific Nitrosamine Ketone N-Oxide
EINECS	Contact for details

Quality Control

Our 4-(Methylnitrosamino)-1-(3-Pyridyl-n-Oxide)-1-Butanone is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and integrity, which is paramount for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation via spectroscopic methods, and impurity profile. We support compliance with relevant Good Laboratory Practice (GLP) and quality standards for reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.