Description

1,3-Diethyl-8-Phenylxanthine is a specialized xanthine derivative with significant biological activity, primarily known for its potent and selective antagonism of adenosine A1 receptors. This compound matters for researchers and developers in the life sciences sector seeking to modulate adenosine signaling pathways, which are implicated in a wide range of physiological processes. It is a critical intermediate and reference standard for pharmaceutical R&D, particularly in the development of neuroprotective agents, cardiac therapeutics, and renal function modulators.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and pharmacologically active compound in the discovery of adenosine receptor antagonists.
• Neuropharmacology Studies: Used in preclinical research to investigate the role of adenosine A1 receptors in neurological conditions, including ischemia, epilepsy, and sleep regulation.
• Cardiovascular Research: Employed as a tool compound to study cardiac function, heart rate, and the protective effects of A1 receptor blockade.
• Renal Function Research: Applied in studies exploring the modulation of renal blood flow and diuresis through adenosine receptor pathways.
• Biochemical Assay Development: Utilized as a high-purity ligand in competitive binding assays and high-throughput screening (HTS) to identify new drug candidates.
• Academic & Institutional Research: A vital reagent for universities and research institutes conducting fundamental studies on purinergic signaling.

Basic Information

Product Name	1,3-Diethyl-8-Phenylxanthine
CAS No.	75922-48-4
Molecular Formula	C₁₅H₁₈N₄O₂
Molecular Weight	286.33 g/mol
Synonyms	8-Phenyl-1,3-diethylxanthine; DPX; 1,3-Diethyl-8-phenyl-3,7-dihydro-1H-purine-2,6-dione; Adenosine A1 Receptor Antagonist DPX; BWA 1433; 1H-Purine-2,6-dione, 3,7-dihydro-1,3-diethyl-8-phenyl-
EINECS	Contact for details

Quality Control

Our 1,3-Diethyl-8-Phenylxanthine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, batch-to-batch consistency, and compliance with relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.