Description

Pyridoxal 5'-Deoxymethylenephosphonate CAS NO 75790-54-4 is a chemically modified analog of pyridoxal phosphate (PLP), a crucial coenzyme in numerous biological processes. This compound is specifically engineered to act as a potent and selective inhibitor of PLP-dependent enzymes, making it an invaluable research tool for probing enzymatic mechanisms and metabolic pathways. It is primarily utilized by researchers and developers in the fields of biochemistry, enzymology, and pharmaceutical development for studying vitamin B6 metabolism and designing targeted therapeutic agents.

Application

• Enzymology Research: As a mechanism-based inhibitor for studying the active sites and catalytic functions of PLP-dependent enzymes such as transaminases, decarboxylases, and racemases.
• Metabolic Pathway Analysis: Used to selectively block specific steps in vitamin B6 metabolism and amino acid biosynthesis for pathway mapping and validation.
• Pharmaceutical R&D: Serves as a lead compound or molecular scaffold in the development of novel enzyme inhibitors for therapeutic applications in neurological disorders and cancers.
• Biochemical Assay Development: Employed as a standard or control reagent in high-throughput screening (HTS) assays to identify new modulators of PLP-dependent enzyme activity.
• Academic Research: A key reagent in university and institutional labs for fundamental research into enzyme kinetics and structure-activity relationships (SAR).

Basic Information

Product Name	Pyridoxal 5'-Deoxymethylenephosphonate
CAS No.	75790-54-4
Molecular Formula	C14H19NO7P
Molecular Weight	344.28 g/mol
Synonyms	Pyridoxal 5'-Deoxymethylenephosphonic Acid; PLP Analog Inhibitor; 4-Pyridoxic Acid 5'-Phosphate Methylenephosphonate; Vitamin B6 Antimetabolite; 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5'-(Deoxymethylenephosphonate); Pyridoxal Phosphate Isoster; PLP Inhibitor 75790-54-4
EINECS	Contact for details

Quality Control

Our Pyridoxal 5'-Deoxymethylenephosphonate is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.