Description

Geldanamycin, 17-Demethoxy-17-[[2-(1-Pyrrolidinyl)Ethyl]Amino]- CAS NO 75747-23-8 is a semi-synthetic derivative of the natural ansamycin antibiotic geldanamycin, designed as a potent and selective inhibitor of Heat Shock Protein 90 (Hsp90). This compound matters for its critical role in disrupting the Hsp90 chaperone function, leading to the degradation of numerous oncogenic client proteins involved in cancer cell proliferation and survival. It is primarily needed by researchers in pharmaceutical R&D, biotechnology, and academic institutions focused on oncology, neurodegenerative disease research, and the development of novel targeted therapeutics.

Application

• Biochemical Research: A key tool compound for studying Hsp90 biology, protein folding, and chaperone-mediated pathways in vitro and in cellular models.
• Oncology Drug Discovery: Serves as a reference standard and lead structure in the development of next-generation Hsp90 inhibitors for cancer therapy.
• Mechanistic Studies: Used to investigate the role of Hsp90 in various disease states, including cancer, neurodegenerative disorders (e.g., Alzheimer's, Parkinson's), and viral infections.
• Signal Transduction Research: Employed to probe Hsp90-dependent signaling networks involving client proteins like AKT, HER2, and mutant p53.
• Preclinical Development: Utilized in pharmacokinetic, pharmacodynamic, and efficacy studies in animal models of disease.
• High-Throughput Screening (HTS): Acts as a positive control in assays designed to identify novel Hsp90 modulators or chemosensitizers.

Basic Information

Product Name	Geldanamycin, 17-Demethoxy-17-[[2-(1-Pyrrolidinyl)Ethyl]Amino]-
CAS No.	75747-23-8
Molecular Formula	C33H47N5O7
Molecular Weight	625.76 g/mol
Synonyms	17-DMAG; 17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycin (common alias); Alvespimycin; NSC 707545; KOS-1022; 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin; 17-AAG analog; Hsp90 Inhibitor 17-DMAG
EINECS	Contact for details

Quality Control

Our Geldanamycin, 17-Demethoxy-17-[[2-(1-Pyrrolidinyl)Ethyl]Amino]- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.