Description

17-AAG (17-Allylamino-17-demethoxygeldanamycin) is a potent and selective inhibitor of the Hsp90 molecular chaperone, representing a critical tool compound in oncology and biochemistry research. Its primary value lies in its ability to induce the degradation of Hsp90 client proteins, many of which are key oncogenic drivers, making it a pivotal molecule for studying cancer cell proliferation and survival pathways. This compound is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on targeted cancer therapy development, signal transduction studies, and proteostasis research.

Application

• Oncology Research: Used as a chemical probe to investigate Hsp90 inhibition and its effects on tumor growth, apoptosis, and metastasis in various cancer cell lines.
• Drug Discovery & Development: Serves as a lead compound and reference standard in the preclinical development of novel Hsp90-targeted anticancer therapeutics.
• Biochemical Studies: Employed to study protein folding, stability, and the role of the Hsp90 chaperone complex in cellular signaling pathways.
• Combination Therapy Research: Investigated for potential synergistic effects when used alongside chemotherapy, radiotherapy, or other targeted agents.
• Mechanism of Action Studies: A key tool for elucidating the degradation mechanisms of oncogenic client proteins like HER2, AKT, and mutant p53.

Basic Information

Product Name	17-AAG
CAS No.	75747-14-7
Molecular Formula	C31H43N3O8
Molecular Weight	585.70 g/mol
Synonyms	17-Allylamino-17-demethoxygeldanamycin; Tanespimycin; NSC 330507; 17-DMAG analog; Geldanamycin, 17-allylamino-17-demethoxy-; CP 127374; KOS-953; BMS 722278
EINECS	Contact for details

Quality Control

Our 17-AAG is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, spectral identification (IR, NMR, MS), and tests for residual solvents and moisture to ensure it meets high-grade research standards. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to warm to room temperature before opening to minimize moisture condensation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.