Description

2,3,5,6-Tetramethylphenylmagnesium Bromide is a highly reactive organometallic Grignard reagent, essential for introducing the sterically hindered 2,3,5,6-tetramethylphenyl (durenyl) group into molecular frameworks. This compound matters for its role as a critical building block in advanced organic synthesis, enabling the creation of complex, high-value specialty chemicals and pharmaceutical intermediates. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing novel aromatic structures.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing sterically hindered biaryl systems and complex aromatic cores found in active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of advanced herbicides and fungicides where the tetramethylphenyl moiety enhances photostability and bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized phosphine and N-heterocyclic carbene (NHC) ligands used in asymmetric catalysis.
• Functional Material Production: Employed in the creation of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) where precise steric control is required.
• Fine Chemical and Flavor/Fragrance Synthesis: Facilitates the introduction of the bulky durenyl group into complex molecules for specialty applications.
• Academic and Industrial R&D: A valuable tool for methodological development in cross-coupling reactions and new bond-forming transformations.

Basic Information

Product Name	2,3,5,6-Tetramethylphenylmagnesium Bromide
CAS No.	75724-98-0
Molecular Formula	C10H13BrMg
Molecular Weight	237.42 g/mol
Synonyms	Durenylmagnesium Bromide; Tetramethylphenylmagnesium Bromide; (2,3,5,6-Tetramethylphenyl)magnesium Bromide; Magnesium, bromo(2,3,5,6-tetramethylphenyl)-; 1,2,4,5-Tetramethylbenzene, bromomagnesio-; Grignard Reagent (Durenyl); Bromo(2,3,5,6-tetramethylphenyl)magnesium
EINECS	Contact for details

Quality Control

Our 2,3,5,6-Tetramethylphenylmagnesium Bromide is manufactured under stringent quality systems. Each batch undergoes rigorous analytical testing, including titration for Grignard concentration and GC/HPLC analysis for purity and solvent composition, to ensure consistency and reliability for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. This product is highly volatile, hygroscopic (moisture-sensitive), and easily oxidized (store under inert atmosphere). For optimal stability, store under a dry, inert gas (argon or nitrogen) at 2-8°C. Keep away from heat, sparks, open flames, and incompatible materials such as moisture, acids, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (in specified solvent)	0.5 M - 2.0 M (Typical)
Assay (by Titration)	≥ 95%
Solvent	THF, Diethyl Ether, or 2-Me-THF
Identification (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.