Description

13-cis-Fenretinide is a synthetic retinoid derivative with significant research and therapeutic potential. This compound is valued for its distinct biological activity profile compared to its all-trans isomer, making it a critical tool in pharmacological and oncology research. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and advanced material scientists for developing novel therapeutic agents and studying cell differentiation and apoptosis pathways.

Application

• Pharmaceutical Research & Development: A key intermediate and active compound in the investigation of novel cancer therapies, particularly for neuroblastoma and other solid tumors.
• Oncology Studies: Used in preclinical and clinical research to study mechanisms of apoptosis (programmed cell death) and cell differentiation in cancer cells.
• Biochemical Reagent: Serves as a high-purity reference standard and reagent in biochemical assays to study retinoid receptor pathways and signaling.
• Academic Research: Employed in university and institutional labs for fundamental studies on the chemopreventive and therapeutic effects of retinoids.
• Drug Formulation Development: Used in the development and testing of novel drug delivery systems, such as liposomal or nanoparticle formulations, to enhance bioavailability.
• Metabolism and Toxicology Studies: Investigated for its metabolic profile and safety in various in vitro and in vivo models.

Basic Information

Product Name	13-cis-Fenretinide
CAS No.	75686-07-6
Molecular Formula	C26H33NO2
Molecular Weight	391.55 g/mol
Synonyms	Fenretinide (13-cis isomer); 4-Hydroxyphenylretinamide (13-cis); 13-cis-N-(4-Hydroxyphenyl)retinamide; 13-cis-HPR; 13-cis-4-HPR; NSC 374551; CCRG 81045; (13Z)-Retinoic acid 4-hydroxyphenylamide
EINECS	Contact for details

Quality Control

Our 13-cis-Fenretinide is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality guidelines to support our clients in pharmaceutical development and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
All-trans-Fenretinide	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤ 20 ppm
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.