Description

Bremazocine CAS NO 75684-07-0 is a potent and selective κ-opioid receptor (KOR) agonist, a key compound in advanced pharmacological research. Its high affinity and selectivity make it an indispensable tool for studying the complex neurobiology of pain, addiction, and mood disorders. This compound is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on central nervous system (CNS) drug discovery and neuropharmacology.

Application

• Neuropharmacological Research: A standard reference compound for investigating κ-opioid receptor signaling pathways and their physiological effects.
• Analgesic Mechanism Studies: Used in preclinical models to study non-addictive, KOR-mediated pain relief and dissociate it from mu-opioid receptor effects.
• Psychiatric Disorder Research: Applied in research exploring the role of the dynorphin/KOR system in depression, anxiety, and stress-related behaviors.
• Substance Abuse Research: Serves as a critical tool for studying the dysphoric and aversive effects associated with KOR activation, relevant to addiction mechanisms.
• Receptor Binding Assays: Employed as a high-affinity radioligand or cold competitor in competitive binding studies to characterize new chemical entities.
• Biochemical Pathway Analysis: Used to elucidate downstream effects of KOR activation, including G-protein coupling and arrestin recruitment (biased agonism).

Basic Information

Product Name	Bremazocine
CAS No.	75684-07-0
Molecular Formula	C₂₅H₃₂N₂O₃
Molecular Weight	408.54 g/mol
Synonyms	(–)-Bremazocine; (2S)-17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(ethylamino)methyl]morphinan; 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(ethylamino)methyl]morphinan; (-)-Bremazocine; Bremazocine Hydrochloride; UM-1071; UM 1071
EINECS	Contact for details

Quality Control

Our Bremazocine is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results for your quality assurance and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.