Description

R(-)-α-Chloromethyl Histamine Dihydrochloride is a high-purity, chiral derivative of histamine, specifically the R-enantiomer of α-chloromethylhistamine. This compound is a critical pharmaceutical intermediate and research chemical used in the development and study of histamine H3 receptor ligands. It is essential for medicinal chemistry research, serving academic institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on neuroscience and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel histamine H3 receptor antagonists and inverse agonists.
• Medicinal Chemistry Research: Used as a precise chiral template for structure-activity relationship (SAR) studies targeting the histaminergic system.
• Neuroscience Drug Discovery: A vital tool compound in preclinical research for potential therapies addressing sleep disorders, cognitive deficits, and obesity.
• Biochemical Assay Development: Serves as a reference standard or ligand in receptor binding assays and functional studies for H3 receptor characterization.
• Academic Research: Utilized in university and institutional labs for fundamental studies on histamine receptor pharmacology and signal transduction.
• Fine Chemical Synthesis: Employed in the custom synthesis of more complex, targeted molecules for clinical candidate optimization.

Basic Information

Product Name	R(-)-α-Chloromethyl Histamine Dihydrochloride
CAS No.	75614-86-7
Molecular Formula	C6H11ClN3·2HCl
Molecular Weight	258.00 g/mol
Synonyms	(R)-α-Chloromethylhistamine Dihydrochloride; (R)-CMH dihydrochloride; (R)-2-(1H-Imidazol-4-yl)ethyl]chloromethane dihydrochloride; (R)-1-(4-Imidazolyl)-4-chloro-2-butanamine dihydrochloride; R(-)-CMH·2HCl; R-α-Chloromethylhistamine 2HCl; (R)-α-Chloromethyl-1H-imidazole-4-ethanamine dihydrochloride; (2R)-2-(1H-Imidazol-5-yl)-1-chloroethylamine dihydrochloride
EINECS	Contact for details

Quality Control

Our R(-)-α-Chloromethyl Histamine Dihydrochloride is manufactured under strict quality control protocols to ensure high chemical and chiral purity suitable for advanced research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to guarantee batch-to-batch consistency and traceability for our pharmaceutical and research clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (R-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.